1 month ago

UAB drug discovery program leads to potential coronavirus breakthrough, underlines importance of genomics project

Work done at the University of Alabama at Birmingham (UAB) has led to the investigational drug remdesivir, which is now being used to treat select infected patients in the United States and China who have been afflicted with novel coronavirus (2019-nCoV).

As outlined by UAB, remdesivir was developed through research conducted through the Antiviral Drug Discovery and Development Center, or AD3C, which is coordinated out of the Birmingham university.

A release from UAB explained that the drug discovery came from a public-private partnership that also included Birmingham-based Southern Research and the pharmaceutical company Gilead Science. The work was funded by a federal grant awarded to UAB after U.S. Senator Richard Shelby (R-AL) became chair of the U.S. Senate Appropriations Committee.

UAB detailed the following:

Remdesivir, developed to treat the coronavirus causing MERS, was found to have significant activity against the 2019-nCoV strain when the outbreak began in the Chinese city of Wuhan. Importantly, remdesivir had demonstrated efficacy in treating other medically important coronaviruses MERS and SARS in cell culture and animal models. Based on the compassionate plea requests of treating physicians in the United States, Gilead Sciences released remdesivir for use in a few patients, although the drug has not yet been tested for safety or efficacy in these diseases.

“The release of remdesivir for safety and efficacy studies is a major accomplishment for the AD3C – namely the U19 grant – as it shows significant and swift advance of antiviral drugs to help treat and respond to emerging infectious disease outbreaks on an international scale and, importantly, to anticipate the introduction of these infections in the United States,” stated Richard Whitley, M.D., distinguished professor at UAB and principal investigator of the grant that led to the discovery.

This kind of groundbreaking research spearheaded by UAB is a prime example of why many legislative and industry leaders in the state, especially in the Birmingham area, are calling on Governor Kay Ivey to fund a world-class genomics facility at the university. They argue that the project could make Birmingham the “Silicon Valley of Biomedicine.”

Read more about that project and its importance here.

Sean Ross is the editor of Yellowhammer News. You can follow him on Twitter @sean_yhn

11 hours ago

Website seeks to connect still-operating local restaurants with Alabama customers

The Alabama Restaurant and Hospitality Association (ARHA) has created a website to try and connect local restaurants with Alabama consumers.

The precautions being taken to slow the spread of the coronavirus have devastated the restaurant industry. A website that tracks the industry estimates that 3% of America’s restaurants have permanently gone out of business since the virus began spreading in the United States.

The website created by ARHA — carryoutal.com — is seeking to prevent that fate for restaurants in Alabama. Visitors are asked to select Carryout, Curbside or Delivery and the site then provides them with the options in their area.

178

The site currently has around 300 restaurants in its database.

There is an option for any locally-owned business to list their establishment for free.

“Most restaurants in Alabama remain open and they need your support more than ever,” says the website’s description.

The site assures any skeptical customers, “While recent governmental orders and recommendations to limit social gatherings have forced restaurants to change the way they operate, the commitment to food safety and sanitation has not changed.”

The ARHA has also created a fund to provide relief for hospitality workers across the state. As of 2:45 p.m on Tuesday, it has raised $1,810 of its $100,000 goal.

Contributions to the fund are tax-deductible.

The description of the fund reads, “On March 19, 2020, restaurants and bars across the state were ordered to close dining area service to the public in an effort to slow the spread of coronavirus. The shutdowns have catastrophically impacted the restaurant and hotel industry.”

Those interested in donating can click here.

Henry Thornton is a staff writer for Yellowhammer News. You can contact him by email: henry@yellowhammernews.com or on Twitter @HenryThornton95.

12 hours ago

Treasury Department issues guidance for small businesses seeking relief funds

The U.S. Treasury Department released new information on Tuesday afternoon for small businesses affected by the COVID-19 crisis. The resources distributed by the agency provide guidance on how to tap into the $340 billion pool of relief funds set aside for the small business sector.

Under the Small Business Administration’s (SBA) Paycheck Protection Program, businesses with fewer than 500 employees are eligible to receive the lesser of $10 million or 2.5 times its payroll over the period of several months.

Banks will distribute the funds in the form of loans granted under criteria contained in the law. Loans may become available as soon as Friday, April 3.

218

Call your banker

That is the advice the Treasury Department is giving to small businesses.

The chairman of the Alabama Bankers Association has stated that banks in his state are ready, willing and able to immediately assist with the small business sector’s recovery.

“Banks in our state are already very familiar with helping customers access SBA funding,” said David Nast, president and CEO of Progress Bank and Trust. “Nearly 94% of banks headquartered in Alabama are SBA-approved lenders, and that number could easily grow higher over the next few weeks.”

RELATED: Alabama banks preparing to assist small businesses with recovery — ‘Call your banker’

Nast echoed the Treasury Department’s advice that interested small businesses should promptly contact their bank.

“Regardless of how banks are interacting with their customers, our advice for individuals and small businesses has been to put ‘Call Your Banker’ near the top of the to-do list,” Nast emphasized.

Info for small businesses

The Treasury Department is maintaining a comprehensive website for those seeking information about the economic stimulus programs it is administering.

Within the site are documents for small businesses to better understand the programs designed for them and how to apply for funds:

Overview of the Payroll Protection Program

Paycheck Protection Program Information for Borrowers

Application for Borrowers

Paycheck Protection Program Information for Lenders

Tim Howe is an owner of Yellowhammer Multimedia

13 hours ago

Jeff Sessions has a clear message for China: The world knows your communist regime is culpable for the Wuhan coronavirus

Former Attorney General and U.S. Senator Jeff Sessions seems to have a clear message for China: The United States will not take your Godless, communist regime’s lying and cheating anymore.

During an appearance on WVNN this week, Sessions said the United States and the world know that China covered up the origins and spread of the virus for months, and we know they are now engaging in a disinformation campaign to shed their culpability.

Sessions on Monday’s broadcast of “The Dale Jackson Show” took some strong punches at China, saying, “It’s a duty we have to explain to the American people, and to the world, really, the danger of this kind of government. It cannot be the dominant government in the world, it will not be if we stand up to it.”

359

Sessions acknowledged that we have allowed this to happen with weak trade and foreign policy. He noted the reaction of the world would be far different if America was responsible.

“Imagine an American company, or American government, had learned about this virus and sat on it for weeks and allowed the world to be infected,” he stated. “I mean, the world would be in an outrage.”

But what can be done?

If elected to his old Senate seat, what will he specifically work to do?

Sessions isn’t the first politician to point out that we can’t allow China to dominate the markets of critical supplies and infrastructure needs, such as medical supplies and high-speed internet.

Specifically, Sessions outlined, “This is one where we need to send a message to China. No. You’re not gonna supply our medicines. Especially when you say you might cut them off. You’re not gonna supply our 5G high tech communications system, high speed. We’re not gonna let you dominate that.”

My takeaway:

This is nothing new for Jeff Sessions.

He has long been a leading critic on China for most of his career. He was calling for us to get tough on China before anyone else even cared.

The world has been too soft on China, and the United States has an obligation to end that. This is our wakeup call. This isn’t about trade, it is about the lives of Americans, which Sessions correctly noted that China’s state-run press has threatened.

America has an obligation to make sure the world knows this coronavirus is the fault of China and punish them for unleashing this on the world.

The coronavirus pandemic proves Jeff Sessions has been correct on China for decades. They lie, cheat and steal to achieve world dominance. He is also right when he says we cannot allow this to continue and our allies around the globe can’t keep turning a blind eye to it or they will win.

China has a plan to continue to dominate globally, and we need people that understand it and know how to combat it at the forefront of this fight.

Listen:

Dale Jackson is a contributing writer to Yellowhammer News and hosts a talk show from 7-11 am weekdays on WVNN.

13 hours ago

Friends launch Local Distancing to support Birmingham businesses

Three friends in Birmingham were wrestling with a major dilemma created by the coronavirus pandemic: How can you lend support to your favorite restaurants and local businesses while maintaining the proper social distancing practices?

Their solution — a pay-it-forward approach. Local Distancing, an online platform, allows customers to help these Birmingham area enterprises pay their staff, cover overhead and survive the crisis without having to leave the security of their home.

Through the Local Distancing web site, consumers can purchase gift certificates from a wide range of restaurants, breweries, retailers and other Birmingham businesses. The site also includes links to GoFundMe accounts for displaced workers.

377

The initiative appears to have struck a chord in the community, with more than 4,000 unique visitors in the first week eager to support more than 150 Birmingham businesses listed on the platform.

“Local businesses are the heartbeat of the Magic City, and they need our help during these challenging times,” said Vince Perez, a senior project manager at the Alabama Department of Commerce and one of the initiative’s founders. “This is a way that all of us can let local business owners and their employees know that we’re in their corner during this crisis.”

The way Local Distancing’s founders see it, buying online gift certificates represents the most practical way for loyal customers to support their favorite local businesses right now while remaining at their homes.

The web site does not charge businesses to participate and will not receive any portion of the gift card purchases. Moreover, it works with gift card processing companies like Square and Gift Up! that provide money immediately to businesses, instead of when the certificates are redeemed.

Instagift, a Birmingham-based firm that provides electronic gift card services to local businesses, is also supporting the effort by waiving monthly fees for new sign-ups and providing promotion on its social media.

Joining Perez in launching Local Distancing are Dylan Spencer, a web developer who built the site and founder of a marketing firm bearing his name, and Trey Oliver, an attorney at the Bradley Arant law firm. The three are childhood friends and all attended Auburn University.

“We all wish we weren’t in this situation, but here we are,“ Spencer said. “Thankfully, hard times have their way of bringing people together, and I believe this will somehow make Birmingham stronger. All we can do for now is stay home, stay healthy, and take care of our city – especially the businesses and restaurants that make it special.”

Local Distancing may just be the perfect substitute for an upcoming anniversary, birthday gift, and more, he said.

“Order food and buy gift certificates, even if to give away as a ‘thank you’ to grocery store workers, restaurant workers, delivery folks, medical workers, and the many others who are working so hard to keep us going,” Spencer urged.

You can also find Local Distancing on Twitter and Instagram under @localdistancing.

(Courtesy of Made in Alabama)

15 hours ago

Video: Ride along with ULA’s Alabama-built rocket on U.S. Space Force’s first national security mission

Alabama’s United Launch Alliance (ULA) teamed up last week with the U.S. Space Force to complete the newly-formed agency’s first national security space mission.

A Decatur-built Atlas V rocket delivered the sixth Advanced Extremely High Frequency (AEHF-6) satellite. The AEHF-6 will enhance the communications capabilities for American warfighters around the world.

The mission became ULA’s 138th overall. With its completion, ULA maintained its 100% mission success rate.

Watch rocket preparation, launch and satellite delivery in space:

13

Tim Howe is an owner of Yellowhammer Multimedia